Leiurotoxin-1 Dab7

SK2 channel blocker

SK2 通道阻斷劑

Leiuorotoxin-Dab7 (Lei-Dab7) is a mutated version of Leiurotoxin, a peptide identified from the venom of the scorpion Leiurus quinquestriatus hebraeus. The Dab amino acid in position 7 confers to this compound a high selectivity for SK2 channels among other channels. Lei-Dab7 exhibits > 200 fold selectivity for SK2 over SK1, SK3, IK, Kv and Kir channels.

Leiurotoxin-1 Dab7技術資料

氨基酸序列：

Ala-Phe-Cys³-Asn-Leu-Arg-Dab-Cys⁸-Gln-Leu-Ser-Cys¹²-Arg-Ser-Leu-Gly-Leu-Leu-Gly-Lys-Cys²¹-Ile-Gly-Asp-Lys-Cys²⁶-Glu-Cys²⁸-Val-Lys-His-NH₂

二硫鍵：Cys³-Cys²¹, Cys⁸-Cys ²⁶ and Cys¹²-Cys²⁸

長度 (aa)：  31

分子式： C₁₄₁H₂₃₆N₄₆O₃₉S₆

分子量：3392.12 Da

外觀：White lyophilized solid

可溶性： water and saline buffer

CAS 號：1061556-49-7 

來源：Synthetic

純度：> 95%

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