嚙齒動物的壽命相對較短，更容易快速繁殖，成本更低，具備可用的基因編輯技術，已經(jīng)建立完善的行為測試方法。然而，大多數(shù)嚙齒動物模型未能再現(xiàn)患者的明顯和典型性神經(jīng)退行性變。

斑馬魚擁有脊椎動物的神經(jīng)結(jié)構(gòu)組織，主要結(jié)構(gòu)都與哺乳動物的大腦相似，具有與人類類似的功能性血腦屏障。斑馬魚生命周期短、繁殖力高，特別適合于大規(guī)模藥物篩選。

大腦發(fā)育、解剖結(jié)構(gòu)、認知和行為復雜性方面與人更接近，大腦比小型動物要大得多并且具備皮質(zhì)表面的折疊，與人的基因相似性更大，病理發(fā)展更類似，具備疾病評估的可用性，但是動物繁殖周期長，價格昂貴，基因修飾技術不夠完善。

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