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商品信息

產(chǎn)品英文名稱(chēng)	Mouse Oncostatin M Protein
產(chǎn)品中文名稱(chēng)	重組小鼠腫瘤抑制素M（OSM）
別名	OSM; OS-M; Oncostatin M

商品屬性

標(biāo)簽	無(wú)標(biāo)簽
表達(dá)宿主	大腸桿菌
種屬	小鼠
序列	氨基酸序列來(lái)源于：重組小鼠腫瘤抑制素M（OSM） (P53347) (Ala24-Arg206) 表達(dá)的蛋白片段。
活性	Testing in Progress
蛋白長(zhǎng)度	重組小鼠腫瘤抑制素M（OSM）由183個(gè)氨基酸組成，預(yù)測(cè)分子量為20.39 KD。
純度	> 99% ，使用SDS-PAGE檢測(cè)
特點(diǎn)&優(yōu)勢(shì)	通過(guò)LAL法測(cè)定，每微克蛋白里內(nèi)毒素含量<1.0>
產(chǎn)品形式	凍干粉，凍干緩沖液為無(wú)菌的20 mM Tris，150 mM NaCl，pH 7.4。
基因ID	18413
蛋白序列鏈接	/uniprotkb/P53347/entry
使用中注意事項(xiàng)	開(kāi)蓋使用前，請(qǐng)先離心。本產(chǎn)品為凍干粉，推薦用該產(chǎn)品配套的Reconstitution Buffer進(jìn)行復(fù)溶，且濃度不低于100 µg/mL。客戶(hù)可根據(jù)后續(xù)的實(shí)驗(yàn)需求，進(jìn)行進(jìn)一步的稀釋。
保存建議	本產(chǎn)品為凍干粉形式，建議：將凍干粉產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后，可在4℃保存2-7天，長(zhǎng)期使用請(qǐng)置于-20℃以下。為長(zhǎng)期保存，推薦添加載體蛋白（0.1% HAS/BSA或11%FBS），并酌情分裝保存，避免反復(fù)凍融。
運(yùn)輸條件	冰袋運(yùn)輸（藍(lán)冰）
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類(lèi)或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

附加信息

背景

Oncostatin M (OSM) is a glycoprotein belonging to the interleukin-6 family of cytokines that has functions mainly in cell growth. Oncostatin M (OSM) is considered as a pleiotropic cytokine that signals through cell surface receptors typeⅠａnd typeⅡ both of which share the similarity of containing protein gp130 and takes part in many bio metabolism processes including liver development, hematopoiesis, inflammation, bone formation, and destruction and possibly CNS development. Oncostatin M (OSM) was previously identified by its ability to inhibit the growth of cells from melanoma and other solid tumors. It also has been reported that OSM, like LIF, IL-6, and G-CSF, can inhibit the proliferation of murine M1 myeloid leukemic cells and can induce their differentiation into macrophage-like cells. The human form of OSM is insensitive between pH2 and 11 and resistant to heating for one hour at 56 degrees but is not stable at 90 degrees. The human OSM is produced as a precursor containing 252 amino acids, whose first 25 amino acids function as a secretory signal peptide and which on removal yields the soluble 227 amino acid pro-OSM. Removal of the C-terminal most 31 amino acids produces the fully active 196 residue form.

圖片及說(shuō)明