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商品信息

產(chǎn)品英文名稱	Mouse GM-CSF protein
產(chǎn)品中文名稱	重組小鼠粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）
別名	CSF; CSF2; CSF-2; GMCSF; GM-CSF;colony stimulating factor 2 (granulocyte-macrophage); granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor; GMCSF, granulocyte-macrophage colony stimulating factor; molgramostin; Sargramostim, MGC131935; MGC138897; Molgramostim;

商品屬性

分子	GM-CSF
標(biāo)簽	無標(biāo)簽
種屬	小鼠
序列	Amino acid sequence derived from Mouse GM-CSF protein isoform (P01587，Met1-Lys141) was expressed.
活性	通過其在FDC-P1細(xì)胞中誘導(dǎo)增殖的能力在0.009-2.5 ng/mL的線性范圍內(nèi)測(cè)量。
蛋白長(zhǎng)度	重組小鼠GM-CSF蛋白由128個(gè)氨基酸組成，預(yù)測(cè)分子量為14.6 kDa。 在還原條件下，SDS-PAGE中小鼠GM-CSF蛋白的表觀分子量約為15-25 kDa。
純度	≥ 90 % ，使用SDS-PAGE檢測(cè)
特點(diǎn)&優(yōu)勢(shì)	采用 LAL 法檢測(cè)，每 1 μg 蛋白質(zhì)中的 EU 含量小于 1.0。
產(chǎn)品形式	凍干粉，凍干緩沖液為無菌的 PBS，pH 7.4。
基因ID	12981
蛋白序列鏈接	/uniprot/P01587
使用中注意事項(xiàng)	開蓋使用前，請(qǐng)先離心。本產(chǎn)品為凍干粉，推薦用該產(chǎn)品配套的Reconstitution Buffer進(jìn)行復(fù)溶，且濃度不低于100 µg/mL。客戶可根據(jù)后續(xù)的實(shí)驗(yàn)需求，進(jìn)行進(jìn)一步的稀釋。
保存建議	本產(chǎn)品為凍干粉形式，建議：將凍干粉的重組小鼠粒細(xì)胞-巨噬細(xì)胞集落刺激因子（GM-CSF）產(chǎn)品保存于-20℃以下的干燥環(huán)境中。本產(chǎn)品溶解之后，可在4℃保存2-7天，長(zhǎng)期使用請(qǐng)置于-20℃以下。為長(zhǎng)期保存，推薦添加載體蛋白（0.1% HSA或者BSA），并酌情分裝保存，避免反復(fù)凍融。
運(yùn)輸條件	常溫運(yùn)輸
警告	本文列出的產(chǎn)品僅供研究使用，不適用于人類或臨床診斷。我們產(chǎn)品所推薦應(yīng)用，不是建議使用我們的產(chǎn)品去違反任何或許可證。對(duì)于使用本產(chǎn)品可能發(fā)生的侵權(quán)或其他違規(guī)行為，我們不承擔(dān)任何責(zé)任。

附加信息

背景

The granulocyte-macrophage colony-stimulating factor (GM-CSF) is an important hematopoietic growth factor and immune modulator. GM-CSF also has profound effects on the functional activities of various circulating leukocytes. It is produced by a variety of cell types including T cells, macrophages, endothelial cells and fibroblasts upon receiving immune stimuli. Although GM-CSF is produced locally, it can act in a paracrine fashion to recruit circulating neutrophils, monocytes and lymphocytes to enhance their functions in host defense. GM-CSF was initially classified as a hematopoietic growth factor. However, unlike its close relatives macrophage CSF (M-CSF) and granulocyte CSF (G-CSF), the majority of myeloid cells do not require GM-CSF for steady-state myelopoiesis. Instead, in inflammation, GM-CSF serves as a communication conduit between tissue-invading lymphocytes and myeloid cells. Even though lymphocytes are in all likelihood the instigators of chronic inflammatory disease, GM-CSF-activated phagocytes are well equipped to cause tissue damage.

圖片及說明